Generally, the vaccines work well against the different variants of SARS-CoV-2, even though the Israeli data seem bad. It may be an outlier.
The South African variant is now called Beta and the Brazilian variant is called Gamma. These are of lesser concern than the Delta/Indian variant which is highly virulent and may infect more people, even when fully vaccinated.
On the other hand, a full vaccination seem to protect extremely well against hospitalisation and death:
My second dose will be tomorrow.
And if you ever wondered how Moderna and then BioNTech was able to produce a vaccine so incredibly quickly, this page tells the story in highlights. After people had worked on mRNA vaccines since the end of the 80’s, Katalin Karikó and Drew Weissman figured out how to make the vaccines safe in 2005. Since then the companies have worked on the specifics – Moderna was already working on a MERS, another coronavirus, vaccine, while BioNTech was working on an influenza vaccine.